There are many different natural things that people can use that work as an anti inflammatory, one being turmeric. Where are the studies that prove this many people ask and since no on is willing to give money on an expensive trial its quite difficult for many to prove this. But there has been a few studies that have confirmed this and what they have discovered will shock you, maybe even throw out all the pills you have at the moment.
Years of studies have been done to prove hat turmeric is one of the top drug compounds, because of the millions of preclinical studies it still sits n the kitchen as a spice rather than something you can use when something is wrong with your body. Here are the most recent studies that have been done on turmeric:
Published in the Indonesian Journal of Internal Medicine in April, 2012, the study, titled Ability of Curcuminoid Compared to Diclofenac Sodium in Reducing the Secretion of Cycloxygenase-2 Enzyme by Synovial Fluid’s Monocytes of Patients with Osteoarthritis, discusses how the curcuminoid extract of turmeric reduced inflammation in patients suffering from knee osteoarthritis.
Osteoarthritis is a rheumatic disease and according to research at the moment it’s the second highest cause of physical disability around the world after heart disease. Just in 2005 1/3 of all the people in America over 65 was suffering with this. Treatment that have been used for this are:
- Analgesics: Pain relievers that include acetaminophen, opioids (narcotics), and an atypical opioid called tramadol
- Non-steroidal anti-inflammatory drugs (NSAIDs): like aspirin, ibuprofen, naproxen and celecoxib
- Corticosteroids: These are extremely powerful and can be taken by mouth or injected directly into a joint at a doctor’s office
- Hyaluronic acid: This acid occurs naturally in joint fluid to protect the infected area, but injections are also done in a doctor’s office
When a person is suffering with OA the synovial fluid (which is in the cavities of the synovial joints) decrease friction inside of the articular cartilage while moving, it cause a great amount of pain from inflammation COX-2 Enzyme activity.
During this one study, researchers linked the effects of NSAID drug diclofenac sodium and curcuminoid extract which had decreased cycloxygenase-2 secrection by synovial fluid’s monocytes. When they performed this they split a group in half that was dealing with osteoarthritis. This is what they discovered:
Curcuminoid from Curcuma domestica Val.rhizome extract significantly suppresses the secretion of COX-2 enzyme by synovial fluid’s monocytes of patients with knee osteoarthritis. The ability of curcuminoid from Curcuma domestica Val. rhizome extract was not significantly different compared to diclofenac sodium in suppressing the secretion of cycloxygenase-2enzyme by synovial fluid’s monocytes.
Simply put, both curcuminoid and diclofenac sodium decreased the secretion of the inflammatory COX-2 enzyme nearly the exact same.
If you compare two toxicities of both the main property in turmeric which is curcumin and diclofenac sodium. When you review they Material Safety sheet you will see a big difference.
- For diclofenac sodium, the LD50 for mice is 95 mg/kg. This means that it would only take 95 mg/kg of mouse to acutely kill 50% of the test population.
- For curcumin, the LD50 for mice is >2,000 mg/kg. This means that it would take more than 2,000 mg/kg of mouse to acutely kill 50% of the test population.
It seems like a no-brainer that people would toss out their pills and pick up turmeric and other natural healing alternatives, or at least give it a try, but the truth of the matter is that people are skeptical to try something with not enough research backing it. While we have covered why this research is lacking, you now undoubtedly have a justified reason to make a change: the natural alternatives won’t harm you.
source: healthyandnaturalhouse
